The shooting happened just before 7 p.m. Sunday on the 7100 block of Elmwood Avenue.
A 33-year-old man was killed and another 33-year-old man is in critical but stable condition.
Investigators told Action News the victims may have been targeted.
Witnesses in the area say they heard the crime taking place.
"It was, 'Pop! Pop! Pop!'" recalled Ishamel Fofana.
Fofana works at a cell phone store a few doors down and listened as the gunfire rang out.
"I saw the one taken in the ambulance to take to the hospital," Fofana said, referring to one of the victims.
Police say two suspects walked into the store, ordered cigars, and then opened fire on the two victims, who were playing the gaming machines.
One victim managed to run out through the back door after being hit several times. The other fell to the floor, where police say the suspects continued shooting him.
In total, police recovered 13 shell casings from inside the store. They also recovered a gun from the man who died.
He had a license to carry, investigators say.
Residents told Action News the convenience store seems to attract a lot of crime in the neighborhood.
One woman, who asked to remain anonymous for her safety, says the city needs to go after stores like this.
"It's a horrible corner, they need to shut it down. It should have been shut down," she said. "Shut it down. Shut all these smoke shops down."
Action News attempted to speak to the owner of the store, but he was out of the country.
Police recovered a gun from the scene but did not make any arrests.
RELATED: Check the 6abc Neighborhood Safety Tracker