The pop superstar announced Friday she is going on an indefinite work hiatus.
Her residency was scheduled to kick off in February at Park Theater at the Park MGM casino-resort.
Spears says she is dedicating her focus and energy to care for her family.
The statement announcing her decision says her father, Jamie Spears, has had a complicated recovery after becoming ill two months ago, undergoing emergency surgery and spending several days at a hospital.
Refunds for "Britney Domination" shows are available at the point of purchase.
Bill Hornbuckle, president of casino operator MGM Resorts International, says the company respects Spears' commitment to her family.
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