It happened around 7:11 p.m. on Boone Avenue.
"All of a sudden I see all these lights. We come outside and there was just smoke everywhere," said Michelle Howarth of Ewing Township.
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Police say officers attempted to get inside the residence, but the flames were too intense.
"There was two people trying to get inside the house, trying to get the lady out, and they were screaming, saying somebody was entrapped in the house," recalled another neighbor who lives nearby.
According to neighbors, a woman lived inside the home with her dog. Police say they were both found dead.
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The cause of the fire remains under investigation.
The name of the victim has not been released.