York County deputies said 52-year-old Lana Clayton confessed to investigators after an autopsy uncovered a high amount of tetrahydrozoline in her husband's body.
The chemical is found in over-the-counter eye drops such as Visine.
Authorities say 64-year-old Stephen Clayton was found dead July 21 in the couple's home in Clover.
Arrest warrants and the statement from deputies didn't give a motive for the alleged poisoning.
Lana Clayton also is charged with malicious tampering with a drug product or food.
Jail records did not indicate if she had a lawyer.
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