It happened before midnight Friday in the northbound lanes of Route 309 bypass, just north of Route 113.
Police say 26-year-old Noelle Chew was driving under the influence when her vehicle collided head-on with another vehicle.
The other driver, 24-year-old Damian Toalombo of Allentown died in the crash.
Chew refused treatment after the collision.
The crash remains under investigation.