The incident happened Wednesday around 12:30 p.m. on the White Horse Pike near Spring Garden Road.
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Officials say the 73-year-old man's SUV collided head on with a box truck when he crossed into oncoming traffic.
The man was later identified as Charles Souza of Texas.
Souza was pronounced dead at the scene.
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The driver of the truck was taken to the hospital and treated for minor injuries.
Authorities are now investigating the cause of that crash.