The flames ignited just before 4 a.m. Saturday on the 4200 block of Passmore Street in Tacony.
Officials say a 40-year-old man intentionally set fire to the house following an argument.
The 35-year-old and 31-year-old women were able to escape from the home.
Investigators say one of the women jumped from a second-floor window.
Medics took both women to Frankford Torresdale Hospital where they are in stable condition.
Police say the suspect sped off in a blue 2004 Ford Windstar mini-van.