The fire broke out just before 5 a.m. on the 3000 block of North Bailey Street.
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Officials said fire crews arrived to find flames shooting from the first floor of a home in the middle of the block.
A man jumped from the second floor of the home to escape the blaze. He was taken to Temple University Hospital in stable condition.
Fire crews evacuated neighboring homes as a precautionary measure.
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The fire was placed under control a short time later, around 5:15 a.m.
Police said at least 13 people have been displaced.
There is no word yet as to what might have caused the fire.