This is happening along the 1900 block of Rhawn Street in the city's Rhawnhurst section.
Firefighters arrived on scene around 4:30 a.m. with smoke showing from the house.
Officials say they initially had trouble finding the woman because of hoarding conditions inside the home.
The victim was found about a half-hour later and taken to Nazareth Hospital.
There's no word what sparked the blaze.