The fire happened Saturday morning on the 1800 block of South 8th Street.
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Officials say firefighters arrived at the scene with heavy smoke conditions showing from a three-story row home.
Firefighters rescued a man from the burning rowhome, officials say.
The victim, whose identity remains unknown, was rushed to the hospital suffering from smoke inhalation and is listed in critical condition.
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The Red Cross has assisted at least 10 people who were displaced by the fire.
There is no word yet on what may have sparked the blaze.