The fire led to the partial collapse of a building on the 6000 block of Lansdowne Avenue in West Philadelphia.
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Firefighters say they got there two minutes after the 10:15 p.m. dispatch, and encountered heavy smoke coming from the middle of a row of storefront buildings.
All three floors of one of the buildings were on fire.
When crews went in to attack the flames, part of the building collapsed.
Officials told Action News that two firefighters had to be hospitalized for smoke inhalation and heat exhaustion.
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They are both in stable condition and are expected to be okay.
Fire crews also took another person to the hospital, but say that person's injuries are not related to the fire.
There is no word yet on what started the blaze.