Among those killed in the "horrific massacre" were a 17-year-old mom and a 6-month-old baby, Tulare County Sheriff Mike Boudreaux told reporters. Both were shot in the head, he said.
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"We do have survivors," the sheriff said, adding that it's not yet clear how they survived.
The Sheriff's Office said it happened shortly after 3:30 a.m. Callers initially thought it was an active shooter situation because of how many shots were fired.
Tulare County sheriff confirms 6 people killed at Goshen home
When deputies arrived, they immediately noticed two victims and then a third in the doorway of the home.
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Deputies found six victims total. All have been declared dead.
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Authorities believe there are at least two suspects at large, Boudreaux said. No arrests have been made.
"We believe that this was a targeted family," the sheriff said.
"This was very personal," Boudreaux said. "We also believe that it was a message being sent."
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Authorities "believe there are gang associations involved in this scene, as well as potential narcotics investigations," Boudreaux said.
"It was like a cartel-style execution," the sheriff said.
One week ago the sheriff's office conducted narcotics search warrants at the house, he said.
ABC News contributed to this report.