It happened at the Double Action indoor shooting range on Industrial Drive in Upper Darby.
Investigators say four men used a circular saw to cut a hole in the roof sometime between Sunday evening and Monday morning.
They say the thieves broke open a case and ran out the back door with 22 handguns.
Upper Darby Police Superintendent Michael Chitwood says they have surveillance video but it has yielded limited information.
Anyone with information is asked to call police.
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