It happened around 8:45 p.m. in the southbound lane of the Turnpike in Hamilton Township, Mercer County.
Chopper 6 was over the wreck involving a bus and at least one car.
Police confirm to Action News that one person has died.
It's unclear if anyone else was injured in the crash or if anyone was on the bus at the time.
Stay with Action News as we continue to follow this developing story.