The driver plowed into an apartment in the city's Logan section, leaving behind a giant hole.
It happened around 4 a.m. Saturday on the 5700 block of South Ogontz Avenue.
No one inside the building was injured, but they were trapped for a short time because the front door was damaged.
Neighbors several houses away heard the crash.
Police say the driver left behind the grill of the pickup truck.
L&I has been called to check the integrity of the building.