Video shows the flames on the 100 block of Saxby Terrace.
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It broke out on the first floor in the rear of the house at 2 a.m.
Two alarms were struck, and more than 50 firefighters were on scene.
Firefighters had received calls of people trapped but were able to get out.
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A couple, both in their 60s, were taken to Jefferson Hospital in Philadelphia for smoke inhalation. They are expected to be ok.
Crews remained on the scene putting out hot spots.
The fire chief spoke to 6abc about the importance of fire safety in the colder months.
"All your basic fire safety principles you want to make sure you're lasered focused on and thinking about as we head into the colder months. Everything from space heaters, to your normal fire prevention -- you want to be mindful of," Cherry Hill Fire Chief Wade Houlihan.
The fire marshal was on scene and the cause of the fire is under investigation.