The fire started after 7 a.m. Saturday on the 1500 block of West Courtland Street.
Firefighters responded after a report of a fire with two women in their 80s trapped inside.
The women escaped the flames and were checked by medics at the scene.
A younger man and a dog also made it out OK.
The victims all appear to be OK. They are keeping warm at a neighbor's home.
Crews were able to get the blaze under control within 15 minutes.
The fire was contained inside a second-floor middle bedroom.
There is no word on what caused the blaze.
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