A police officer rushed into the home and rescued a second person.
The fire happened just after 1:30 a.m. Saturday in the unit block of 9th Street in Upland Township.
When crews arrived on scene, smoke and flames could be seen coming from the basement.
Both people pulled from the home were hospitalized and treated for smoke inhalation.
Six adults and two children escaped the fire with no injuries.
The cause of the fire is under investigation.