It happened on the 3900 block of North 6th Street just before 2:30 a.m. Sunday.
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Police say a man in his 20s was shot multiple times in the head and a 36-year-old man was shot four times.
The man in his 20s was transported to Temple University Hospital, where he was pronounced dead.
A private vehicle transported the 36-year-old victim to the same hospital, where he was placed in stable critical condition.
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Police say the private vehicle fled the area before officers arrived.
No arrests have been made in this incident.