It happened after 10 p.m. Thursday at Courtland and Boudinot streets.
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Police say the two victims were sitting in the vehicle when someone approached them and opened fire on the passenger side.
A 24-year-old man was shot in the leg, and a 22-year-old woman was shot in the back.
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Both victims were rushed to Temple University Hospital in stable condition
It is not clear if the two were targeted.
So far, no arrests or word on a motive.