The crash happened on I-295 just before 8:30 a.m. between Creek Road (Exit 43) and RT-38 (Exit 40).
Police said a van the victim was driving hit a pickup truck, causing the van to veer off the road and overturn. That's when it also got hit by a tractor-trailer.
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Chopper 6 was overhead, where you could see the jack-knifed semi and a red vehicle that was severely damaged.
Jack-knifed tractor-trailer, another vehicle severely damaged after crash on SB I-295 in N
Officials said 62-year-old Dennis Cox from Mercer County, New Jersey, has died as a result of the crash.
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There is no word yet on what caused the crash.