The crash happened around 10:17 a.m. Friday just south of Philadelphia Pike.
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Chopper 6 over the scene showed one of the three vehicles involved in the crash severely damaged and hanging on the guardrail.
Chopper 6: Crash shuts down I-495 in Claymont
No injuries have been reported.
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All traffic was originally being diverted on to I-95. Crews have since opened the shoulder to allow traffic through as they continue to investigate and clear the scene.