The crash was first reported at about 3:30 a.m. near US-322. It shut down the southbound lanes until about 7:30 a.m.
RELATED: Traffic maps and cameras from across the region
Police said one of the drivers, Joshua Singleton, of Chester, Pa., was killed in the crash.
At least three vehicles were involved, authorities said.
A second driver was taken to an area hospital to be treated. There was no update on that person's condition.
Additional information about the crash was not yet made available.