It happened around 10 p.m. Sunday as two drivers traveled southbound on the highway near mile marker 12, the Philadelphia International Airport exit.
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Police say the drivers pulled their vehicles over and began fighting.
During the fight, police say one driver pulled out a gun and shot the other.
Police say the shooting victim, described as a man in his 50s, then got back in his car and drove to a Sunoco gas station on the 400 block of Lincoln Avenue in Prospect Park where he called 911.
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Arriving troopers found the man suffering from a gunshot wound to his backside. His condition has not been released.
The Action Cam showed a vehicle at the gas station with a damaged windshield.
There is no description of the shooter at this time.