The crash occurred around 5:15 a.m. on I-95 south just below the Naamans Road exit.
Police said firefighters worked for approximately 20 minutes to free the driver from the car.
There is no word on the driver's condition.
A portion of I-95 southbound was closed just before the Delaware state line for some time Sunday morning as the scene was cleared.
Traffic was diverted off of the highway at the Naamans Road exit, which caused significant delays.