It happened around 10:15 p.m. Tuesday on the southbound lanes of the highway in Lehigh County.
Officials tell Action News the crash involved two tractor-trailers, a passenger van carrying 10 people, an SUV and at least three other vehicles.
At least one person had to be cut out of their vehicle, but there was no immediate word on the conditions of the victims.
Crews worked for a few hours to clear the southbound lanes, but the road has since reopened.
The cause of the crash is still under investigation.