Authorities say a tractor-trailer carrying heavy equipment hit the bottom of an overpass while traveling northbound on Interstate 295.
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It happened at the Route 140 Bridge Overpass in Carney's Point on Tuesday.
Transportation officials say the collision caused significant damage to the overpass.
I-295 had been closed since the crash while repairs were made.
The highway reopened just after 4 a.m. Friday.
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"I know there was some concern, some conversation that 295 was going to be closed for months - that's not the case. At some point it may have to be closed again - maybe not the entirety of the roadway - when we fix 140 up above, but that's not going to be for quite a while," said NJ DOT Commissioner Diane Gutierrez.