It happened just before 5 p.m. on the eastbound lanes of the highway near mile marker 347.3 (Passyunk Avenue).
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The victim told police she had honked her horn at a dark-colored minivan in front of her as she was entering the I-76 East on-ramp from Grays Ferry Avenue.
Investigators say the minivan then began driving erratically and got behind the victim's vehicle as she entered I-76.
As she was traveling along the highway right before the Passyunk exit, the minivan pulled up along the driver's side of the victim's car and fired two shots.
The gunfire struck the vehicle. The victim and passenger were uninjured, according to police.
After the shooting, the minivan quickly took the exit and continued on I-76 East towards the Walt Whitman.
Police described the suspect vehicle as a dark-colored minivan with a broken passenger-side rear tail light. Officers also said the rear windshield was missing and had been covered with a black tarp.
I-76 was shut down in that area for about two hours after the incident.
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Officers are still working to determine what led up to the gunfire. Pennsylvania State Police are also involved in the investigation.
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