It happened around 1:23 p.m. on I-95 northbound at Penn's Landing near the Columbus Boulevard ramps.
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A victim told police the operator of a black sports motorcycle fired several gunshots into his mini-van while on the highway.
Police say the suspect then fled the scene after the shooting.
Further details on what sparked the gunfire have not been released.
Video from Chopper 6 showed a minivan stopped on the highway with multiple Pennsylvania State Police vehicles nearby.
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Authorities have not said if the victim suffered any injuries.
The highway near the shooting scene was briefly closed.
Anyone with information is asked to call the Pennsylvania state police at 215-452-5216.