The crash happened just after 9 p.m. Saturday just before Exit 3 (Highland Avenue) in Upper Chichester Township.
Police say the driver of the blue Ford F-150 pickup was traveling in the right lane of I-95 northbound when the driver swerved onto the right shoulder.
The pickup then hit a motorcycle, another truck, and a pedestrian.
Police say the driver of the blue F-150 then fled onto Exit 3 without stopping.
The pedestrian who was hit, only identified as a 44-year-old man, was pronounced dead at the scene.
Police are asking the public, including auto body shops, to keep an eye out for the truck.
If you have any information, you are asked to call state police at 484-840-1000.