It all began shortly before 8 p.m. Thursday at a McDonald's in Brookhaven on the 4200 block of Edgemont Avenue.
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The suspects reportedly took a store cash register and fled in a Chevy Tahoe.
Area police agencies spotted the vehicle and pursued it on I-95 southbound at Highland Avenue.
The vehicle then crashed in the median near Route 322.
I-95 southbound was temporarily closed at the crash scene. It has since reopened.
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Two people were reportedly taken into custody.
Police continue to search the area for other possible suspects.
No injuries were reported.