The single vehicle crash happened around 3:30 a.m. Saturday when a passenger van loaded with several people ran off the Interstate-95 southbound just past the Woodhaven Road.
Police say the van rolled over several times, injuring fourteen people and trapping several inside the vehicle.
Several ambulances were involved in getting the victims to four different hospitals.
It is not clear on the severity of the injuries or why the van veered off the road.
Interstate-95 southbound was closed between Woodhaven and Academy roads, but has since reopened.