According to police, the shooting happened at about 8:10 p.m. on the 1300 block of South 50th Street.
All four men were taken to Penn Presbyterian Medical Center.
A 40-year-old man was shot once in the right arm. Police said he is listed in critical condition.
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A 22-year-old man and a 21-year-old man were each shot in the right leg. They are listed in stable condition.
A 28-year-old man was shot once in the right thigh and suffered a graze wound to the chest. He is listed in stable condition.
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No arrests have been made.
No additional information has been released.