It happened just after 2 a.m. on the 6400 block of Rising Sun Avenue.
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Police said the victim was standing on the street with his girlfriend when the shooter approached and shot him once in the head.
The 37-year-old man was taken by police to Albert Einstein Medical Center where he was pronounced dead a short time later.
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There is no word on a motive for the shooting.
There have been no arrests made at this time.