It happened just after 2 a.m. on the 6400 block of Rising Sun Avenue.
Police said the victim was standing on the street with his girlfriend when the shooter approached and shot him once in the head.
The 37-year-old man was taken by police to Albert Einstein Medical Center where he was pronounced dead a short time later.
There is no word on a motive for the shooting.
There have been no arrests made at this time.