The fire started around 5:15 a.m. Friday on the 3000 block of Lawrenceville Road (Route 206).
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Crews arrived to find heavy smoke and flames.
A second alarm was struck as the fire spread through the home.
Firefighters had to bring in water tankers due to a lack of water supply in the area.
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Chopper 6 over the scene showed not much was left of the home after the fire.
Drivers are advised to take alternative routes near the fire scene.
A cause is under investigation.