It happened just before 11 p.m. on the 4900 block of North 13th Street.
Police said the man was hit three times, in the back, chest and head.
He was taken to the hospital where he was pronounced dead a short time later.
Police said the killer was wearing a bright construction-type vest.
Investigators are checking nearby real-time cameras for suspects.
So far there is no word on a motive.