Officers responded to a burglary call at the residence on the 2500 block of Waterford Road in Lower Makefield Township around 3 p.m. Friday.
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When they arrived, they reportedly saw 23-year-old Trevor Weigel, of Churchville, stabbing his 19-year-old ex-girlfriend outside her home.
The woman, who has not been identified, was pronounced dead at the scene.
Officers then chased after the suspect who fled to the area of I-295. When officers caught up to him, police say he was stabbing himself in the neck.
Authorities say officers used a Taser on the suspect before taking him to an area hospital.
Chopper video showed officers cordoning off a large portion of the neighborhood. Residents who live in the Brookstone Condos are upset and shocked after their young neighbor was violently killed.
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"Great neighborhood. Something like this is just horrible," said neighbor Bill Walsh.
"It's really sad and really devastating that somebody was here and now gone just a couple of hours ago," added Victor Miranda who lives in the area.
Police say Weigel underwent surgery for life-threatening injuries at the hospital. There was no word on his condition.
Authorities are trying to determine what led up to the deadly stabbing. Investigators are also looking into Weigel's criminal history. Records show he has traffic violations in Bucks County.
"It's terrible. It shouldn't happen. It's sad for the whole family," said Lower Makefield Township Police Captain Jason Braim.