They will attend the "Once Upon A Wish Party," a princess-themed ball.
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6abc's parent company, Disney, teamed up with the Make-A-Wish Foundation for one of their biggest wish-granting events.
"I am going to go to Disney World," says 5-year-old Sloane Capaldo from South Philadelphia.
She can't wait to see her favorite princesses.
"I am most excited to see Belle and Ariel," Capaldo says.
Shortly after she turned one, Capaldo developed a rash. Her pediatrician sent the family to the Children's Hospital of Philadelphia for bloodwork.
"And then, all of a sudden, a whole team comes in the room in the emergency room to tell us that Sloane had leukemia," recalls Capaldo's mother, Lyndsay.
"It's heart-wrenching as a parent to watch your child go through this. She was so young that there was no way to explain it to her," she continued.
Capaldo is now in remission and has been off treatment since last year.
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So now, it's time to make some wishes come true.
"I took all my medicine and that's why I get to go to the ball," Capaldo says. "I'm brave and strong!"
Her father, Jonathan, says the support has been truly overwhelming.
"These are memories that are going to last a lifetime for her," he says. "I think this encapsulates how special she really is."
Lily Ruiz, 8, from Middletown, Delaware, will also be at the ball.
"My wish was to have a tea party with Belle," Ruiz says.
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The Ruiz family found out last year that the pain in their daughter's arm was a sign of something more serious.
"Lily has a very rare form of leukemia," says her mother, Jackie.
Treatment was long, and the road to remission has been bumpy. But finally, Ruiz was medically cleared for this royal moment.
"Lily is the most resilient, strong-willed, brave, courageous, just full-of-joy, little girl," her mother said.
And now, the whole family is headed to Orlando to celebrate.
Ruiz and Capaldo are two of 100 guests invited to the "Once Upon a Wish Party" for Make-A-Wish at Walt Disney World.
The festivities run through August 26.