It happened around 2:30 a.m. Saturday near the Level 38 bar on the 3800 block of Lancaster Avenue.
Investigators said four bullets struck a 24-year-old man.
He was taken by a private vehicle to Penn Presbyterian Medical Center in critical condition.
A man in his 30s was shot in leg and was able to walk a block to the same hospital, police said.
Police found 14 shell casings outside of the bar.
No arrests have been made.