The incident happened Monday just before 5 p.m. on the 3300 block of Princeton Avenue.
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Police say a 33-year-old man was shot once in the right thigh.
He was taken to Jefferson Frankford Hospital, where he was listed in stable condition.
A 23-year-old man was also shot once in the stomach.
He was transported by private vehicle to Nazareth Hospital.
The 23-year-old was later transported by medics to Temple University Hospital, where he was listed in critical condition and being held as a prisoner.
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Police say the robber shot the homeowner, and the homeowner returned fire.
A gun was also recovered from the scene, officials say.
No further details have been provided at this time.