Melissa Ortiz-Rodriguez, 30, left her home in Collingdale on April 19, 2013, to visit a friend. She was never seen or heard from again.
Her estranged husband, Jose Rodriguez, reported her missing five days later.
Investigators secured a search warrant to check her husband, but to this day, officials haven't named a possible suspect in Ortiz-Rodriquez's disappearance.
READ | Police interview daughters of missing Collingdale, Pa. woman
At the time she went missing, her daughters were seven and 11 years old.