Greis Dominguez-Millan and Daniela Alvarado-Regalado were last seen on Saturday.
The two were last seen in Malvern, Pa. around 3 p.m.
Police say they may be "at special risk of harm or injury."
Dominiguez-Millan is about four feet tall with dyed red hair with black streaks. Alvarado-Regalado is 4'9" tall with black hair.
Anyone with information is asked to dial 911 or East Whiteland Twp. police at 610-647-1440.