The crash happened at about 2:50 p.m. on the southbound lanes of I-295 near exit 20. Investigators said it involved a FedEx truck and a Ford dump truck.
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One person was killed in the crash, authorities said. That person's identity has not yet been released.
1 dead following truck crash on I-295 in New Jersey
The crash closed all four southbound lanes of I-295.
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The cause of the accident remains under investigation.