The crash happened at about 2:50 p.m. on the southbound lanes of I-295 near exit 20. Investigators said it involved a FedEx truck and a Ford dump truck.
One person was killed in the crash, authorities said. That person's identity has not yet been released.
1 dead following truck crash on I-295 in New Jersey
The crash closed all four southbound lanes of I-295.
The cause of the accident remains under investigation.