It happened around 2:28 p.m. on I-195 at milepost 0.1, right at the I-295 interchange.
New Jersey State Police say the crash involved a box truck, a GMC Envoy and a Mini-Cooper.
It appears the cab of the truck got caught along the edge of a grassy median with the trailer portion coming to a rest on the road below.
Crews freed the truck just after 8:30 p.m.
Multiple injuries have been reported but police say they are all believed to be non-life threatening.