The accident occurred around 2 p.m. Friday outside the Minquas Fire Company No. 1, located near the intersection of North James and East Justis streets.
Police say a Ford Fusion and Saturn collided, causing the Saturn to overturn and strike a pole.
A woman inside the Saturn was trapped for about 30 minutes while crews worked to free her.
She was rushed by medics to Christiana Hospital with serious, but nonlife-threatening injuries.
No other injuries were reported.