The fire was reported around 4:30 a.m. in the 400 block of Mahogany Walk.
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Police officers were the first to arrive at the scene to find the fire erupting from a two-story townhouse.
The officers tried to get inside but were driven back by the smoke and flames.
The victim was found dead in a second-floor bedroom after the fire was extinguished.
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The woman who died was described as a senior citizen, but no further details on her identity have been released.
Fire officials say everyone else in the home has been accounted for.
An investigation into the cause of this fire continues.