Officers began chasing the white Chrysler minivan in Cranbury, Middlesex County.
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Chopper footage showed about one dozen police cars in pursuit with lights flashing.
Shortly before 6 p.m. police used their vehicles to box in the minivan and bring it to a stop near exit 6 in Florence Township.
Troopers approached the minivan with their guns drawn and pointed at the vehicle.
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The names of the two people taken into custody have not been released.
It's not yet known why police were chasing the vehicle.