Officers began chasing the white Chrysler minivan in Cranbury, Middlesex County.
Chopper footage showed about one dozen police cars in pursuit with lights flashing.
Shortly before 6 p.m. police used their vehicles to box in the minivan and bring it to a stop near exit 6 in Florence Township.
Troopers approached the minivan with their guns drawn and pointed at the vehicle.
The names of the two people taken into custody have not been released.
It's not yet known why police were chasing the vehicle.